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The main idea behind tk_happy is to allow a fully "wired" Tkinter application to be quickly created (Tkinter is the python interface to Tk). The users main responsibility is to add logic to the Tkinter framework created by tk_happy.
xbgtk - an xbase/Harbour/xHarbour object-oriented wrapper for using the GTK+ GUI. This project has been deprecated in favour of https://github.com/tuffnatty/hbgi, an approach that uses GObject Introspection for automatic bindings.
Kefir is a code sketcher based on tepache that uses pygtk and libglade. Kefir creates a set of wrapper classes around the top level glade widgets in a glade file, to allow the programmer to concentrate on writing a program instead.