Antibodies have 2 identical light chains and 2 identical heavy chains held together via disulfide bonds. On tip of variable region (=tip of Y) is the Antigen-binding region= contains specific code (found by hypermutation= rapid code finding through trail and error) that is then clonally selected= type chosen for binding to antigen. Rest of antibody= constant region. Isotype switching= changing Ig isotypes (IgA, IgG, IgM, IgE, IgD).