Not a DOI
The resolution service at https://doi.org resolves DOIs. You have attempted to resolve dm5migu4zj3pb.cloudfront.net/manuscripts/43000/43343/small/JCI43343.f6.gif, which is not a DOI.
dm5migu4zj3pb.cloudfront.net/manuscripts/43000/43343/small/JCI43343.f6.gif may be a Handle (DOIs are a special sort of Handle). If dm5migu4zj3pb.cloudfront.net/manuscripts/43000/43343/small/JCI43343.f6.gif is a valid Handle you should be able to resolve it at https://hdl.handle.net.
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