Niall McCarroll wrote a neat little AWS S3 cache on his blog that I found really useful, but could not find on PyPI, so here it is in a refactored form as a public service.
from s3cache import S3Cache
s3 = S3Cache("/tmp", "t13d-misc")
s3.connect()
s3.create_bucket()
assert(s3.bucket_exists())
s3.set_verbosity(True)
s3.set_caching(True)
f = s3.open("/tmp/world.txt", "w")
f.write("Hello")
f.close()
f = s3.open("/tmp/world.txt", "a")
f.write(" World")
f.close()
f2 = s3.open("/tmp/world.txt", "r")
f2.close()
assert(s3.object_exists("/tmp/world.txt"))
s3.remove_object("/tmp/world.txt")