FLOW CHART FOR CAPSULES
APPROVED RAW MATERIALS
& Control temp. & humidity
EXCIPIENTS
Check for SIFTING
Sieve size
(Time as per the Product SOP)
MIXING In-process analysis for mixed
powder
Check temp. & FILLING In-process checks
humidity (DT, Wt. Variation)
POLISHING
Sorting of breakage capsules
Analysis for filled capsules
Output READY FOR PACKING
FINAL PACKING
TRANSFER TO F.G. STORE
DISPATCH
CAPSULES :
In capsules, the drug in powder form with or with out suitable fillers after mixing are filled in pre-formed
hard gelatin capsule shells. For this use of drum mixer, manual / semi automatic capsule filling machine
is made. After filling the capsules are polished & inspected with help of capsules polishing machine.
Entire processing is done under controlled temperature humidity conditions with the help of Air
conditioners Dehumidifiers. Packing is done with help of counters or strip/blister packing machine.
FLOW CHART FOR AVALEH
APPROVED RAW MATERIALS
&
EXCIPIENTS
Check for EXTRACTION
Sieve size
pH adjustment
MIXING/VOLUME MAKING Analysis of mixed mass
BY BASE/VEHICLE TO
DESIRED MASS
In-process checks FILLING & SEALING Batch printing
Final testing
PACKING
TRANSFER TO F.G. STORE
DISPATCH
FLOW CHART FOR OINTMENTS
APPROVED RAW MATERIALS
&
EXCIPIENTS
Check for SIFTING
Sieve size
Analysis of mixed bulk
(Time as per the Product SOP) paste
MIXING
Batch coding FILLING & SEALING In process checks
Analysis of filled
tubes
PACKING
TRANSFER TO F.G. STORE
DISPATCH
PROCESS FLOW DIAGRAM OF CHURNA
RAW MATERIAL
RECEIPT
MIXING/ BLENDING OF
POWDER/GRANULES & COLOUR etc.
SIEVING
QUALITY CONTROL
ASSEMBLING IN MFG ROOM
FILLING POUCH/SEALING
FINISHED PRODUCT
QUALITY CONTROL
CARTONING/ PACKING
TRANSFER TO F.G. STORE
DISPATCH
PROCESS FLOW DIAGRAM OF ARISTA/ASAVA
RAW MATERIAL
RECEIPT
EXTRACTION OF HERBS AND
BLENDING WITH GUDA
(FERMENTATION)
FERMENTED FOR 21 DAYS
FILTERATION
FINISHED PRODUCTS
FILLING , SEALING & LABEL
PACKING IN MASTER CARTOON &
SEALING
QUALITY CHECK
QUALITY CONTROL
PACKING
TRANSFER TO F.G. STORE
DISPATCH
PROCESS FLOW DIAGRAM
OF
GHRITA
MURCHA OF GHEE (VEHICLE)
Drug Analysis of mixed suspension/
Solution/Suspension solution
Making
KWATH PREPD OF HERBS In process checks
KWATH MIXED WITH GHEE
BOILING THE MIXTURE UNTIL WATER
REMOVED
FILTER, COOLED
QUALITY CONTROL
PACKING IN GLASS CONTAINER
TRANSFER TO F.G. STORE
DISPATCH
FLOW CHART FOR OIL
APPROVED RAW MATERIALS
&
EXCIPIENTS
AQUEOUS EXTRACT PREPN. OF Testing of Distilled Water
HERBS
Vials/Ampoules EXTRACT IN OIL VEHICLE pH Adjustment &
Washing Volume make
Analysis of bulk solution
FILTERATION OF OIL EXTR
Vials/Ampoules
Sterilization in VOLUME MAKE UP BY BASE OIL In-process Checks
D.H.S. AND COLOR, FRAGRANCE
MIXING & FILTRATION
Check for Final analysis of product
Particulate matters FILL, SEAL & LABEL
FINAL PACKING
TRANSFER TO F.G. STORE
DISPATCH
FLOW CHART FOR TABLETS/ GUTIKA
Approved Raw Materials
& Excipients
Check for Sieve Size SIFTING
Approved Raw Materials & Excipients
(Time as per the product SOP)
MIXING
(Time as per the Product SOP)
KNEADING
(Time as per the Product SOP)
GRANULATION
(Time & Temp. as per the Product SOP)
DRYING
Check for Sieve Size (Time as per the product SOP)
SIZE REDUCTION
Check for material (Time as per the Product SOP) In-process analysis for Granules
addition LUBRICATION
Check the dies & punches COMPRESSION
In-process checks
(DT, Wt. Variation etc.)
Analysis for un-coated tablets
DEDUSTING & INSPECTION
Tablets free from Foreign/black particles
FILM COATING
& VISUAL INSPECTION Analysis for film-coated tablets
Output
FINAL PACKING
TRANSFER TO F.G. STORE
DISPATCH
TABLETS :
Since most of the drugs can not be compressed as such to make suitable tablets, they have to be
converted to free flowing granular form & other inert excepients have to be added to modify drug
availability characteristics. Thus use of sifter is done to screen & select suitable sized particles, Mass
mixer/Rapid mixer granulator is used for granulation/binding, tray drier & fluid bed dryers are used for
drying purpose. Granulation/ Cadmill is used for size reduction & for final mixing lubrication -Ribbon
blender is used. Mixed granules are compressed on suitable Rotary compression machines with in-
process controls. They are coated (sugar coated are film coated) if required using suitable coating &
polishing pans.
Then they are packed using Strip/Blister machine or bulk packed with counting devices if so required.
FLOW CHART FOR LIQUID
ORALS(PANAK/SYRUP/DROPS)
APPROVED RAW MATERIALS
&
EXCIPIENTS
Check for SIFTING
Sieve size
D.M.WATER
PREPARATION Testing of D.M. Water
SYRUP
PREPARATION
Bottle MIXING IN S.S.TANK pH Adjustment & Volume
Washing
Analysis of bulk solution
FILTER THE SYRUP/ SUSP. PASS
THROUGH COLLOID
Bottle Drying FILLING & SEALING In-process Checks
Checking of Final analysis of product
Glass INSPECTION
& Foreign particles
FINAL PACKING
TRANSFER TO F.G. STORE
DISPATCH
Mixing
Grinding
Bulk Testing
Gelatin melting & colouring Molding & Filling
In-process check
Cleaning/Washing
Drying
Inspection
Packing
ORAL LIQUIDS :
The manufacture of liquid orals generally involves the following steps:-
Step I : Preparation of sugar syrup :
D.M. water is added to the stainless steel tank along with the required quantity of sugar and stirred till
it is completely dissolved.
Step II : Addition of Ingredient
Various ingredients are separately dissolved and added to the sugar syrup prepared
in Step I. pH is then adjusted.
Step III : Filtration & Filtering
The solution so prepared is filtered through a filter press, the clarity of solution is
checked and then filled in bottles.
However, the method of manufacture for each dosage form will vary depending upon
the formulations and are given in pharmacopoeias. The proprietary and patent
preparations of the said dosage forms are manufactured as per the method developed by
the manufacturers and approved by the drug licensing authority.
