SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

Revision Date 14.07.2018 Version 22.0

SECTION 1. Identification of the substance/mixture and of the company/undertaking

1.1 Product identifier

Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

REACH Registration Number This product is a mixture. REACH Registration Number see section 3.

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses Reagent for analysis, Chemical production

In compliance with the conditions described in the annex to this safety
data sheet.

1.3 Details of the supplier of the safety data sheet

Company Merck KGaA * 64271 Darmstadt * Germany * Phone:+49 6151 72-0

Responsible Department LS-QHC * e-mail: [email protected]

1.4 Emergency telephone Please contact the regional company representation in your country.
number

SECTION 2. Hazards identification

2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)

Oxidizing liquid, Category 3, H272

Corrosive to metals, Category 1, H290
Acute toxicity, Category 3, Inhalation, H331
Skin corrosion, Category 1A, H314

For the full text of the H-Statements mentioned in this Section, see Section 16.

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

2.2 Label elements

Labelling (REGULATION (EC) No 1272/2008)

Hazard pictograms

Signal word
Danger

Hazard statements
H272 May intensify fire; oxidizer.
H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
H331 Toxic if inhaled.
EUH071 Corrosive to the respiratory tract.

Precautionary statements
Prevention
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
Response
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.

Reduced labelling (≤125 ml)

Hazard pictograms

Signal word
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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

Danger

Hazard statements
H314 Causes severe skin burns and eye damage.
H331 Toxic if inhaled.

Precautionary statements
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.

2.3 Other hazards

None known.

SECTION 3. Composition/information on ingredients

Chemical nature Aqueous solution
3.1 Substance
Not applicable

3.2 Mixture

Hazardous components (REGULATION (EC) No 1272/2008)

Chemical name (Concentration)
CAS-No. Registration number Classification
nitric acid (>= 65 % - < 70 % )
Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.

7697-37-2 01-2119487297-23-
XXXX Oxidizing liquid, Category 2, H272
Corrosive to metals, Category 1, H290
Acute toxicity, Category 1, H330
Skin corrosion, Category 1A, H314

For the full text of the H-Statements mentioned in this Section, see Section 16.

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

SECTION 4. First aid measures

4.1 Description of first aid measures
General advice
First aider needs to protect himself.

After inhalation: fresh air. Call in physician.

If breathing stops: immediately apply artificial respiration, if necessary also oxygen.

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower. Call a physician immediately.

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove
contact lenses.

After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of
perforation). Call a physician immediately. Do not attempt to neutralise.

4.2 Most important symptoms and effects, both acute and delayed
Irritation and corrosion, Cough, Shortness of breath, Bloody vomiting, death, Risk of blindness!
The following applies to nitrites/nitrates in general: methaemoglobinaemia after the uptake of
large quantities.

4.3 Indication of any immediate medical attention and special treatment needed
No information available.

SECTION 5. Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the surrounding
environment.

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

5.2 Special hazards arising from the substance or mixture

Not combustible.

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

Has a fire-promoting effect due to release of oxygen.

Ambient fire may liberate hazardous vapours.
Fire may cause evolution of:
nitrous gases, nitrogen oxides

5.3 Advice for firefighters

Special protective equipment for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.

Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Cool closed containers
exposed to fire with water spray. Prevent fire extinguishing water from contaminating surface
water or the ground water system.

SECTION 6. Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid substance contact. Do not breathe vapours,
aerosols. Ensure adequate ventilation. Evacuate the danger area, observe emergency
procedures, consult an expert.

Advice for emergency responders: Protective equipment see section 8.

6.2 Environmental precautions

Do not empty into drains.

6.3 Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills.
Observe possible material restrictions (see sections 7 and 10).
Take up with liquid-absorbent and neutralising material (e.g. Chemizorb® H⁺, Merck Art. No.
101595). Dispose of properly. Clean up affected area.

6.4 Reference to other sections

Indications about waste treatment see section 13.

SECTION 7. Handling and storage

7.1 Precautions for safe handling

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

Advice on safe handling

Observe label precautions.

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and
face after working with substance.

7.2 Conditions for safe storage, including any incompatibilities

Requirements for storage areas and containers
No metal or light-weight-metal containers.

Storage conditions
Tightly closed. Do not store near combustible materials. Keep locked up or in an area accessible
only to qualified or authorised persons.

Recommended storage temperature see product label.

7.3 Specific end use(s)

See exposure scenario in the Annex to this MSDS.

SECTION 8. Exposure controls/personal protection

8.1 Control parameters
Derived No Effect Level (DNEL)
nitric acid (7697-37-2)
Worker DNEL, Local effects inhalation 1,3 mg/m³
longterm

Predicted No Effect Concentration (PNEC)

nitric acid (7697-37-2)
PNEC no data available

8.2 Exposure controls

Engineering measures

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.

See section 7.1.

Individual protection measures

Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.

Eye/face protection
Tightly fitting safety goggles

Hand protection
full contact:
Glove material: Viton (R)
Glove thickness: 0,7 mm
Break through time: > 480 min

splash contact:
Glove material: natural latex
Glove thickness: 0,6 mm
Break through time: > 120 min

The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 890 Vitoject® (full contact), KCL
706 Lapren® (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Other protective equipment

Acid-resistant protective clothing

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

Respiratory protection
required when vapours/aerosols are generated.
Recommended Filter type: Filter E-(P3)
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.

Environmental exposure controls

Do not empty into drains.

SECTION 9. Physical and chemical properties

9.1 Information on basic physical and chemical properties

Form liquid

Colour colourless

Odour stinging

Odour Threshold 0,27 ppm

(anhydrous substance)

pH <1
at 20 °C

Melting point ca. -32 °C

Boiling point/boiling range 121 °C

at 1.013 hPa

Flash point Not applicable

Evaporation rate No information available.

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

Flammability (solid, gas) No information available.

Lower explosion limit No information available.

Upper explosion limit No information available.

Vapour pressure ca.9,4 hPa

at 20 °C

Relative vapour density No information available.

Density 1,39 g/cm3

at 20 °C

Relative density No information available.

Water solubility at 20 °C
soluble

Partition coefficient: n- No information available.

octanol/water
Auto-ignition temperature No information available.

Decomposition temperature Distillable in an undecomposed state at normal pressure.

Viscosity, dynamic No information available.

Explosive properties Not classified as explosive.

Oxidizing properties The substance or mixture is classified as oxidizing with the

category 3.

9.2 Other data

Ignition temperature Not applicable

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

Corrosion May be corrosive to metals.

SECTION 10. Stability and reactivity

10.1 Reactivity
strong oxidising agent

10.2 Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

10.3 Possibility of hazardous reactions

Risk of explosion with:

Acetone, acetonitrile, acetylidene, Alcohols, ANILINE, antimony hydride, arsenic hydride, Organic
Substances, Benzene, phosphides, anilines, Amines, Halogenated hydrocarbon, Diethylether,
dimethyl ether, hydrazines, Nitro compounds, Sulphides, Dioxane, acetic acid, Acetic anhydride,
ethanol, Ethylene glycol, Fluorine, formaldehyde, rubber, oils, Hydrazine hydrate, Hydrocarbons,
Copper, lithium silicide, organic solvents, Manganese, Cyanides, Powdered metals, Methanol,
petrol, PHOSPHORUS TRICHLORIDE, phosphorus hydrogen, anhydrides, Reducing agents,
sulphur dioxide, Boranes, thiocyanates, Titanium, toluene, Impurities, Nitric acid, hydrogen
peroxide, Tin, sugars, xylene, dichloromethane, carbon/soot

potassium chlorate, with, Organic Substances

mercury(II) nitrate, with, ethanol

Organic Substances, with, sulphuric acid

Nitrobenzene, with, sulphuric acid

potassium permanganate, with, Alcohols

glycerol, with, sulphuric acid

Risk of ignition or formation of inflammable gases or vapours with:

Amines, Ammonia, combustible substances, Aldehydes, furfuryl alcohol, hydrogen iodide,

Potassium, Lithium, magnesium, phosphides, sodium, hydrides, phosphorus, pyridine, hydrogen
sulphide, THIOPHENE

Violent reactions possible with:

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

Nitriles, antimony, arsenic, Boron, ferric oxide, alkalines, sodium hypochlorite, formic acid,
halogen-halogen compounds, Germanium, glycerol, nitrides, Sodium hydroxide solution, Sodium
hydroxide, sulphuric acid, selenium, Bismuth, chlorates

10.4 Conditions to avoid

no information available

10.5 Incompatible materials

Cellulose, Metals
Contact with metals may lead to the formation of nitrous gases and hydrogen.

10.6 Hazardous decomposition products

in the event of fire: See section 5.

SECTION 11. Toxicological information

11.1 Information on toxicological effects
Mixture

Acute oral toxicity

Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation
of the oesophagus and the stomach.

Acute inhalation toxicity

Symptoms: burns of mucous membranes, Cough, Shortness of breath, Possible damages:,

damage of respiratory tract, After a latency period:, Inhalation may lead to the formation of
oedemas in the respiratory tract.
Acute toxicity estimate: 4,62 mg/l; 4 h ; vapour
Calculation method

Acute dermal toxicity

This information is not available.

Skin irritation
Mixture causes severe burns.

Eye irritation

Mixture causes serious eye damage. Risk of blindness!

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

Sensitisation
This information is not available.

Germ cell mutagenicity

This information is not available.

Carcinogenicity
This information is not available.

Reproductive toxicity
This information is not available.

Teratogenicity
This information is not available.

Specific target organ toxicity - single exposure

This information is not available.

Specific target organ toxicity - repeated exposure

This information is not available.

Aspiration hazard
This information is not available.

11.2 Further information

After uptake:
Bloody vomiting, strong pain (risk of perforation!), tissue damage, death
The following applies to nitrites/nitrates in general: methaemoglobinaemia after the uptake of
large quantities.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.

Components

nitric acid
Acute inhalation toxicity
LC50 Rat: > 2,65 mg/l; 4 h ; vapour
OECD Test Guideline 403

Germ cell mutagenicity

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

Genotoxicity in vitro
Ames test
Salmonella typhimurium
Result: negative
Method: OECD Test Guideline 471

SECTION 12. Ecological information

Mixture
12.1 Toxicity
No information available.
12.2 Persistence and degradability
Biodegradability

The methods for determining the biological degradability are not applicable to inorganic
substances.
12.3 Bioaccumulative potential
No information available.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
Substance(s) in the mixture do(es) not meet the criteria for PBT or vPvB according to Regulation
(EC) No 1907/2006, Annex XIII, or a PBT/vPvB assessment was not conducted.
12.6 Other adverse effects
Additional ecological information
Biological effects:
Harmful effect due to pH shift. Forms corrosive mixtures with water even if diluted. Does not
cause biological oxygen deficit. Hazard for drinking water supplies.
Discharge into the environment must be avoided.

Components
nitric acid

Biodegradability

The methods for determining the biological degradability are not applicable to inorganic substances.

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

Partition coefficient: n-octanol/water

log Pow: -2,3
OECD Test Guideline 107
Bioaccumulation is not expected.

Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.

Henry constant
2482 Pa*m³/mol
Method: (calculated)
(Lit.) Distribution preferentially in air.

SECTION 13. Disposal considerations

Waste treatment methods
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.

SECTION 14. Transport information

Land transport (ADR/RID)

14.1 UN number UN 2031

14.2 Proper shipping name NITRIC ACID

14.3 Class 8 (5.1)

14.4 Packing group II

14.5 Environmentally hazardous --

14.6 Special precautions for yes

user

Tunnel restriction code E

Inland waterway transport (ADN)

Not relevant

Air transport (IATA)

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

14.1 UN number UN 2031

14.2 Proper shipping name NITRIC ACID

14.3 Class 8 (5.1)

14.4 Packing group II

14.5 Environmentally hazardous --

14.6 Special precautions for yes

user Not permitted for transport

Sea transport (IMDG)

14.1 UN number UN 2031

14.2 Proper shipping name NITRIC ACID WITH AT LEAST 65% BUT NOT MORE THAN
70%

14.3 Class 8 (5.1)

14.4 Packing group II

14.5 Environmentally hazardous --

14.6 Special precautions for yes

user
EmS F-A S-Q

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant

SECTION 15. Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
EU regulations
Major Accident Hazard SEVESO III
Legislation OXIDIZING LIQUIDS AND SOLIDS
P8
Quantity 1: 50 t
Quantity 2: 200 t

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

SEVESO III
ACUTE TOXIC
H2
Quantity 1: 50 t
Quantity 2: 200 t

Occupational restrictions Take note of Dir 94/33/EC on the protection of young people at
work.

Regulation (EC) No 1005/2009 on substances that not regulated

deplete the ozone layer

Regulation (EC) No 850/2004 of the European not regulated

Parliament and of the Council of 29 April 2004 on
persistent organic pollutants and amending
Directive 79/117/EEC

Substances of very high concern (SVHC) This product does not contain substances
of very high concern according to
Regulation (EC) No 1907/2006 (REACH),
Article 57 above the respective regulatory
concentration limit of ≥ 0.1 % (w/w).

National legislation
Storage class 5.1B

15.2 Chemical safety assessment

For this product a chemical safety assessment was not carried out.

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

SECTION 16. Other information

Full text of H-Statements referred to under sections 2 and 3.

H272 May intensify fire; oxidizer.

H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
H330 Fatal if inhaled.
H331 Toxic if inhaled.

Training advice
Provide adequate information, instruction and training for operators.

Labelling
Hazard pictograms

Signal word
Danger

Hazard statements
H272 May intensify fire; oxidizer.
H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
H331 Toxic if inhaled.
EUH071 Corrosive to the respiratory tract.

Precautionary statements
Prevention
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
Response
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.

Key or legend to abbreviations and acronyms used in the safety data sheet

Used abbreviations and acronyms can be looked up at www.wikipedia.org.

Regional representation
This information is given on the authorised Safety Data Sheet for your country.

The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

EXPOSURE SCENARIO 1 (Industrial use)

1. Industrial use Reagent for analysis, Chemical production)

Sectors of end-use
SU 3 Industrial uses: Uses of substances as such or in preparations at industrial sites
SU9 Manufacture of fine chemicals
SU 10 Formulation [mixing] of preparations and/ or re-packaging (excluding alloys)

Chemical product category

PC19 Intermediate
PC21 Laboratory chemicals

Process categories
PROC1 Use in closed process, no likelihood of exposure
PROC2 Use in closed, continuous process with occasional controlled exposure
PROC3 Use in closed batch process (synthesis or formulation)
PROC4 Use in batch and other process (synthesis) where opportunity for exposure arises
PROC5 Mixing or blending in batch processes for formulation of preparations and articles
(multistage and/ or significant contact)
PROC8a Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large
containers at non-dedicated facilities
PROC8b Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large
containers at dedicated facilities
PROC9 Transfer of substance or preparation into small containers (dedicated filling line, including
weighing)
PROC10 Roller application or brushing
PROC15 Use as laboratory reagent

Environmental Release Categories

ERC1 Manufacture of substances
ERC2 Formulation of preparations
ERC4 Industrial use of processing aids in processes and products, not becoming part of articles
ERC6a Industrial use resulting in manufacture of another substance (use of intermediates)
ERC6b Industrial use of reactive processing aids
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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

2. Contributing scenarios: Operational conditions and risk management measures

2.1 Contributing scenario controlling environmental exposure for: ERC1, ERC2, ERC4, ERC6a, ERC6b

Technical conditions and measures / Organizational measures

Water Solutions with low pH-value must be neutralized before
discharge.

2.2 Contributing scenario controlling worker exposure for: PROC1

Product characteristics
Concentration of the Substance in Covers the percentage of the substance in the product up to
Mixture/Article 100 %.

Physical Form (at time of use) Medium volatile liquid

Process Temperature < 31 °C

Frequency and duration of use

Frequency of use 8 hours/day
Frequency of use 5 days/week

Other operational conditions affecting workers exposure

Outdoor / Indoor Indoor without local exhaust ventilation (LEV)

Conditions and measures related to personal protection, hygiene and health evaluation
Wear suitable gloves (tested to EN374), coverall and eye protection.

2.3 Contributing scenario controlling worker exposure for: PROC2, PROC3

Product characteristics
Concentration of the Substance in Covers the percentage of the substance in the product up to
Mixture/Article 100 %.

Physical Form (at time of use) Medium volatile liquid

Process Temperature < 31 °C

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

Frequency and duration of use

Frequency of use 8 hours/day
Frequency of use 5 days/week

Other operational conditions affecting workers exposure

Outdoor / Indoor Indoor with local exhaust ventilation (LEV)

Conditions and measures related to personal protection, hygiene and health evaluation
Wear suitable gloves (tested to EN374), coverall and eye protection.

Wear respiratory protection. Effectiveness (of a measure): 90 %

2.4 Contributing scenario controlling worker exposure for: PROC4, PROC5, PROC8a, PROC8b, PROC9,
PROC10, PROC15

Product characteristics
Concentration of the Substance in Covers the percentage of the substance in the product up to
Mixture/Article 100 %.

Physical Form (at time of use) Medium volatile liquid

Frequency and duration of use

Frequency of use 8 hours/day
Frequency of use 5 days/week

Other operational conditions affecting workers exposure

Outdoor / Indoor Indoor with local exhaust ventilation (LEV)

Conditions and measures related to personal protection, hygiene and health evaluation
Wear suitable gloves (tested to EN374), coverall and eye protection.

Wear respiratory protection. Effectiveness (of a measure): 95 %

3. Exposure estimation and reference to its source

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Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

Environment
CS Use descriptor Msafe Compartment RCR Exposure Assessment Method

2.1 ERC1, ERC2, ERC4, All compartments Qualitative assessment

ERC6a, ERC6b

Workers
CS Use descriptor Exposure duration, route, effect RCR Exposure Assessment Method

2.2 PROC1 longterm, inhalative, local 0,02 MEASE

2.3 PROC2 longterm, inhalative, local 0,10 MEASE

2.3 PROC3 longterm, inhalative, local 0,25 MEASE

2.4 PROC4 longterm, inhalative, local 0,20 MEASE

2.4 PROC5 longterm, inhalative, local 0,50 MEASE

2.4 PROC8a longterm, inhalative, local <1 MEASE

2.4 PROC8b longterm, inhalative, local 0,59 MEASE

2.4 PROC9 longterm, inhalative, local 0,50 MEASE

2.4 PROC10 longterm, inhalative, local <1 MEASE

2.4 PROC15 longterm, inhalative, local 0,10 MEASE

The default parameters and -efficiencies of the applied exposure assessment model were used for
the calculation (unless stated differently).
For (other) local effects risk management measures are based on qualitative risk characterisation.

4. Guidance to Downstream User to evaluate whether he works inside the boundaries set by the Exposure
Scenario

The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 22 of 26
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

Please refer to the following documents: ECHA Guidance on information requirements and chemical
safety assessment Chapter R.12: Use descriptor system; ECHA Guidance for downstream users;
ECHA Guidance on information requirements and chemical safety assessment Part D: Exposure
Scenario Building, Part E: Risk Characterisation and Part G: Extending the SDS; VCI/Cefic REACH
Practical Guides on Exposure Assessment and Communications in the Supply Chain; CEFIC
Guidance Specific Environmental Release Categories (SPERCs).

The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 23 of 26
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

EXPOSURE SCENARIO 2 (Professional use)

1. Professional use Reagent for analysis, Chemical production)

Sectors of end-use
SU 22 Professional uses: Public domain (administration, education, entertainment, services,
craftsmen)

Chemical product category

PC21 Laboratory chemicals

Process categories
PROC15 Use as laboratory reagent

Environmental Release Categories

ERC2 Formulation of preparations
ERC6a Industrial use resulting in manufacture of another substance (use of intermediates)
ERC6b Industrial use of reactive processing aids

2. Contributing scenarios: Operational conditions and risk management measures

2.1 Contributing scenario controlling environmental exposure for: ERC1, ERC2, ERC4, ERC6a, ERC6b

Technical conditions and measures / Organizational measures

Water Solutions with low pH-value must be neutralized before
discharge.

2.2 Contributing scenario controlling worker exposure for: PROC15

Product characteristics
Concentration of the Substance in Covers the percentage of the substance in the product up to
Mixture/Article 100 %.

Physical Form (at time of use) Medium volatile liquid

Frequency and duration of use

Frequency of use 8 hours/day

The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 24 of 26
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

Frequency of use 5 days/week

Other operational conditions affecting workers exposure

Outdoor / Indoor Indoor with local exhaust ventilation (LEV)

Conditions and measures related to personal protection, hygiene and health evaluation
Wear suitable gloves (tested to EN374), coverall and eye protection.

Wear respiratory protection. Effectiveness (of a measure): 80 %

3. Exposure estimation and reference to its source

Environment
CS Use descriptor Msafe Compartment RCR Exposure Assessment Method

2.1 ERC1, ERC2, ERC4, All compartments Qualitative assessment

ERC6a, ERC6b

Workers
CS Use descriptor Exposure duration, route, effect RCR Exposure Assessment Method

2.2 PROC15 longterm, inhalative, local <1 MEASE

The default parameters and -efficiencies of the applied exposure assessment model were used for
the calculation (unless stated differently).
For (other) local effects risk management measures are based on qualitative risk characterisation.

4. Guidance to Downstream User to evaluate whether he works inside the boundaries set by the Exposure
Scenario

Please refer to the following documents: ECHA Guidance on information requirements and chemical
safety assessment Chapter R.12: Use descriptor system; ECHA Guidance for downstream users;
ECHA Guidance on information requirements and chemical safety assessment Part D: Exposure
Scenario Building, Part E: Risk Characterisation and Part G: Extending the SDS; VCI/Cefic REACH
Practical Guides on Exposure Assessment and Communications in the Supply Chain; CEFIC
Guidance Specific Environmental Release Categories (SPERCs).

The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 25 of 26
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No. 100456

Product name Nitric acid 65% for analysis EMSURE® Reag. Ph Eur,ISO

The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 26 of 26