K. B.

RAVAL COLLEGE OF PHARMACY

B.PHARM SEM 1 2024
PHARMACEUTICAL ANALYSIS
QUESTION BANK
Chapter 1(a): Basics of Pharmaceutical Analysis

1. Define pharmaceutical Analysis. Explain scope of it.

2. What you mean by Analytical method? Classify it with examples.
or
Compare and contrast Classical method and Instrumental method.
or
Give advantages and disadvantages of Classical method and Instrumental method.
3. Define Following terms: Normality, Molarity, Molality, Mole fraction, %v/v, %w/w and
%w/v.
Or
Explain methods of expressing concentration
4. Write a note on Standardization.
5. Define: Primary Standard compound, Secondary Standard compound.
6. Give preparation and Standardization of Oxalic Acid,
7. Give preparation and Standardization of Sodium Hydroxide.
8. Give preparation and Standardization of sodium Thiosulphate.
9. Give preparation and Standardization of HCl.
10. Give preparation and Standardization of sulfuric Acid.
11. Give preparation and Standardization of kmno4.
12. Give preparation and Standardization of cerric Ammonium sulphate.

Chapter 1(b): Errors

13. Write a note on error science.
or
14. Explain sources of error.
15. Explain types of error.
16. Write a note on minimization of error.
17. Explain: Precision, Accuracy, significant figures

Chapter 1(c): Errors

18. Write a short note on Pharmacopoeia.
19. Explain sources of impurities.
20. Explain in detail limit test with example.

COMMENTS:

1. Classical methods are superior over instrumental methods.

2. Random errors are easily avoidable type of error.
3. Limit tests are quantitative in nature,

DIFFERENCES:

1. Classical method and instrumental method

2. Systemic error and non systemic error.
 K. B. RAVAL COLLEGE OF PHARMACY
B.PHARM SEM 1(2017)
PHARMACEUTICAL ANALYSIS
QUESTION BANK
Chapter 2(i): Acid Base Titration:

1. Explain theories of Acd and base.

2. Write a note on Buffer.
3. Explain Common ion effect.
4. Write a note on Law of Mass Action.
5. Explain pH equation.
6. Write a note on hydrolysis of salt with any one example.
7. Explain ionization of water.
8. Classify acid base titration with examples.
9. Write a note on end point detection in Acid Base Titration.
Or
Explain Quinonoid theory and resonance theory.
Or
Write a note on neutralization indicators(pH indicators)
10. Write a note on neutralization curves.
 K. B. RAVAL COLLEGE OF PHARMACY
B.PHARM SEM 1(2017)
PHARMACEUTICAL ANALYSIS
QUESTION BANK
Chapter 2(ii): Non aqueous Titration:

1. Write a note on Non aqueous Titration.

2. Write a note on Non aqueous solvents.
Or
Define: Amphiprotic, Aprotic, Protophillic and Protogenic solvents
3. Write a note on effects of solvent in Non aqueous Titration.
Or
Explain leveling effect and differentiating effect
4. Explain estimation of Sodium Benzoate and ephedrine hydrochloride.:

DIFFERENCES:

1. Acidimetry and Alkalimetry

 K. B. RAVAL COLLEGE OF PHARMACY
B.PHARM SEM 1(2017)
PHARMACEUTICAL ANALYSIS
QUESTION BANK
Chapter 3: Precipitation Titration:

1. Write a note on Precipitation Titration.

2. Explain Solubility Product Constant and its application.
3. Note on factors affecting ksp.
4. Enlist end point detection methods in Precipitation Titration. Explain the method which gives
coloured ppts at the end of reaction.
Or
Write a note on Mohr’s method.
Or
Write a note onVolhard’s method.
Or
Write a note on fajan’s method (adsorption indicator method).
5. Explain estimation of NaCl.

Comments:
1. Nitrobenzene is added in and Volhard’s method.
2. Volhard’s method is carried out at alkaline media.
3. Mohr’s method is carried out at acidic media.
4. Value of ksp increases with higher temperature.
5. Ksp is only applicable for unsaturated solutions.
6. Mohr’s method is used for estimation of iodides.
7. Volhard’ s method is used for estimation of all the halides.

Differences:
1. Mohr’s method and Volhard’s method.
2. Mohr’s method and fajan’s method.
3. fajan’s method and Volhard’s method.
Chapter 5 Gravimetry:

1. Give a brief note on Gravimetric Analysis.

2. Write a note on co-precipitaton and post precipitation.
3. Explain estimation of Barium Sulphate.
4. Write a note on Digestion.
5. Explain following terms: A)Gravimetry B)Ageing C) Coprecipitation
D) post precipitation

Chapter 6: Redox Titration

1. Explain concept of Redox Titration.

2. Explain indicators used in Redox Titration.
3. Enlist types of Redox Titration. Explain any one of it.
Or
Write a note on Iodine type of titration.
Or
Write a note on Mercuric Titration.
Or
Write a note on Cerimetric Titration.
Or
Write a note on Diazotization.
Or
Write a note on Bromatometry.
4. Give principle and application of Redox Titration.
5. Give Difference between Iodimetric Titration and Iodometric Titration.
6. Explain following terms: a) Self indicator b) internal indicator c) Redox Half reaction.
7. Write a note on end point detection in Redox Titration.

Comments:

1. Kmno4 is act as a self indicator.

2. Iodimetric Titration is considered as a direct method while Iodometric titration is indirect
method.
3. Starch indicator is not used in acidic media.
4. Starch indicator is added towards the end of titration in Iodometric titration.
5. Diazotization titration is only used for primary aromatic amino groups.
 Chapter 7: Conductometry
1. What you mean by Analytical method? Explain types of it.
2. Briefly explain Conductometry.
3. Define conductance and explain factors affecting it.
4. Give details on Kohlrausch’s law.
5. Write a note on instrumentation of Conductometry.
6. Explain types of Conductometric Titration.
7. Explain following terms: 1) Specific conductance 2)Equivalent conductance 3) Molar
conductivity 4) Wein effect 5) Debye Falkenhagan effect 6)Asymmetric effect
7) Electrophoretic effect

Comments:
1. On Dilution overall conductance increases.
2. Temperature control is necessary during Conductometric Titration.
3. Stronger electrolyte produces greater increase in conductance.

Chapter 8: Potentiometry

1. Explain briefly Potentiometry.

2. Write a note on Electrodes used in Potentiometry.
3. Draw a schematic diagram of Calomel electrode.
4. Write a note on Indicator Electrode.
5. Explain Glass Electrode.
6. Explain end point detection in Potentiometry.
7. Give Application of Potentiometry.
8. Explain construction and working of reference electrode.

Chapter 9: Polarography

1. Write a note on Polarography.

2. Explain typical current voltage curve.
3. Give a detail account on factors affecting Polarogram.
4. Explain: 1)limiting current 2) Residual current 3)Migration current 4)Convection current
5) Diffusion current 6) Polarographic maxima
5. Write a note on factors affecting Diffusion current.
6. Give working and construction of DME.
7. Explain application of Polarography.
8. Explain illkovic equation.
9. Explain rotating platinum electrode.
10. Write a note on Polarographic Analysis.

Comments:

1. Gelatin or detergent is added during Polarographic Measurement.

2. Supporting Electrolyte is added during Polarographic Measurement.