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  • University of Wisconsin Madison
  • Madison, WI

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@smith-chem-wisc

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nbollis/README.md

Hi there! I'm Nic 👋

I'm a chemist and open-source developer passionate about mass spectrometry, bioinformatics, and building tools that bridge proteomics and epitranscriptomics.

🔬 Research Interests

  • Proteomics & Epitranscriptomics: I study how proteins and RNA are modified, digested, and identified via high-resolution LC-MS/MS workflows.
  • Spectral Analysis: My work thus far includes spectral averaging, chimeric spectra deconvolution, and charge state prediction.
  • FDR & Post-processing: I'm especially interested in machine learning approaches to false discovery rate control for proteomic search identifications.

Check out my Google Scholar for recent publications.

🧪 Software Projects

  • MetaMorpheus: Core developer of this open-source search engine for proteomics and RNA modification analysis. I contribute to backend algorithms and WPF GUI features.
  • MzLib & Related Libraries: Developer and maintainer of modular .NET libraries supporting mass spectrometry workflows, with emphasis on testability and reusability.
  • Transcriptomics Extensions: Developer of workflows for modified RNA oligonucleotide analysis alongside standard peptide searches.

🛠️ Personal Projects

Beyond my research and scientific tools, I enjoy building practical and fun software projects to learn new skills, including:

  • 🃏 Solitaire Solver with Genetic Algorithms
    A simulation environment for evolving and testing solitaire strategies using genetic algorithms and automated game state evaluation.

  • 🎲 Board Game Stats Tracker
    A stats tracker for tabletop games, designed to log game outcomes, player performance, and generate fun historical summaries.

  • 🍲 Recipe Management Software
    A desktop app to organize, categorize, and scale personal and family recipes with intuitive meal planning tools.

🛠️ Languages & Tools

C# XAML .NET WPF R SQL

Popular repositories Loading

  1. MetaMorpheus MetaMorpheus Public

    Forked from smith-chem-wisc/MetaMorpheus

    Proteomics search software with integrated calibration, PTM discovery, bottom-up, top-down and LFQ capabilities

    C# 1

  2. FourSoulsStatsTracker FourSoulsStatsTracker Public

    Statistic tracker and data vIsualization for the Binding of Issac Four Souls card game

    C# 1

  3. nbollis nbollis Public

    My Personal Repository

    1

  4. mzLib mzLib Public

    Forked from smith-chem-wisc/mzLib

    Library for mass spectrometry projects

    C#

  5. TheKitchen TheKitchen Public

    recipe and inventory manager for personal use

    C#

  6. InstrumentControl InstrumentControl Public

    C# 2